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On the basis of this consensus, we defined electrophysiological abnormality according to the presence of at least one abnormal nerve conduction parameter in both dominant-side sural and peroneal nerve distributions using the Counterpoint instrument (Natus Medical Incorporated, San Carlos, CA) (6).
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By this consensus approach we defined the two final sets of dysregulated and preserved miRNA categories.
Consistent with international consensus definitions, we defined sepsis events as hospitalization for infection plus two or more systemic inflammatory response syndrome (SIRS) criteria.
Given a consensus sequence, we define a "possible crossover" as any two adjacent SNPs S j and S k, where no haplotype assembly supports (covers and agrees with) at both S j and S k.
For the purposes of this study, we defined consensus as a "general agreement of a substantial majority" (>75%) [ 13].
Prior to data collection [ 11, 19], we defined consensus as 75percentnt or more responses falling within a two-point bracket on a response scale [ 15, 20].
To both give population size a degree of freedom and to match with a consensus estimate of human populations, we defined a gamma prior distribution with a mean of ∼10,000 individuals and a 95% confidence interval of 3,000 to 21,000 individuals [39], [40].
We defined the consensus donor sequence from rice using 10,000 non-alternatively spliced donor sites as AG|GTAWGN.
We defined a consensus on the importance of teaching a topic as receiving a score of 4 (very important) or 5 (essential) from a simple majority of panelists.
Based on these and other data, we defined different consensus binding sequences for Mash1 (GCAGSTGK or CAGSTG) and Ngn2 (CANTWG) (Additional file 7).
Since this approach still failed to detect previously recognized human κB sites, we defined a consensus κB sequence covering all functional κB elements described in NOS-2 promoters (NFKB-NOS2, see Methods).
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