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An important future direction will be discussion and engagement with myeloma working groups and integration of these data into consensus risk stratification criteria to ensure communication and adoption throughout the global myeloma community.
However before inclusion into such studies, children must be staged according to consensus risk criteria.
39 In resected GISTs, standard histologic description must be completed by the mitotic count, which was evaluated in 50 hpf in the 2002 consensus risk classification.
Degree of consensus: strong consensus Risk communication is defined as communication about the probabilities of expected benefits and the possible risks of harm by HT, with the patient and possibly with an accompanying person.
These considerations led to the adoption of a consensus risk classification based on the combination of the maximal tumor size and the mitotic count per 50 high-power fields (hpf) in 2002 (Table 1A).
Tumors were classified using standard risk assessment criteria using both the classification proposed by Fletcher (NIH consensus risk) [ 18], which is based on tumor size and number of mitoses, and the classification proposed by Miettinen [ 19], which is based on the MI, tumor size, and tumor site.
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The authors believe that seeking complete consensus risks a 'lowest common denominator' effect, with the exclusion of otherwise highly-rated indicators because they were opposed by one or two individuals with a strong contrary opinion.
These data are similar to the IMWG consensus on risk stratification where low-risk patients had low/intermediate disease stage and no genetic factors, and intermediate-risk was defined by either (a) ISS I plus t(4 14) or del17p, or (b) ISS III with no genetic factors.
We see Poundland as most exposed to further consensus downgrade risk.
Currently, there is no consensus on risk factors for adverse outcome.
Chng WJ, Dispenzieri A, Chim CS, Fonseca R, Goldschmidt H, Lentzsch S, et al. IMWG consensus on risk stratification in multiple myeloma.
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