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Nonetheless, the results were consistent with those of DAVID, Consensus Pathways, and STRING PPIs databases.
Our results show that changes in metabolic and signaling pathways, including the consensus pathways implicated in aging, are evident as early as 5 months of age.
Therefore, we asked a question whether the consensus pathways can be also derived using the proposed strategy from the readouts of the coherent studies.
Though rod photoreceptors are highly specialized neurons involved in photoreception, we identified changes in consensus pathways of aging, including oxidative phosphorylation and stress response affecting transcription and inflammation (Figure 5).
Similarly, genome-wide expression profiling studies have revealed candidate genes that reinforce consensus pathways but also demonstrate tissue-specificity [1], [13], [16], which likely has implications for aging-associated diseases of specific tissues.
The observed consensus pathways of T cell development, including requirements for ZAP-70, LAT, SLP-76, and Vav1, appear to reflect the restriction by Cbl of an otherwise much broader set of molecular pathways capable of mediating T cell development.
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Biological processes related to the signature genes (Consensus Pathway Database, release 31 (http://ConsensusPathDB.org)).
We also checked the Consensus Pathway database with the same genes (see Additional file 4: Table S1).
To include additional biological processes less represented in DAVID, another public resource used was the Consensus Pathway Database, release 31 (http://ConsensusPathDB.org) as a complement.
Nationwide standards, guidelines, and experiences across disciplines were reviewed, and a consensus pathway evolved for cervical spine clearance in children 8 years and younger.
As mentioned above in the section "Biological processes related to the selected genes," several biological processes related to the immune system were found significantly associated with higher SUV values in the Consensus Pathway database.
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