Sentence examples for consecutive mutation from inspiring English sources

Importantly, the identified SNPs are not homogeneously distributed along the chromosomes, and we could identify 166 regions in which the three consecutive mutation occur within 200 bases (density is larger than 5 SNPs/kb).

The constraint dup  +  mut  ≤  ins implies that it never costs more to replace an insertion of some letter α into some nonempty string by the duplication of a letter β adjacent to the insertion position, and its consecutive mutation to α.

First, the predicted SmpB interaction site of SsrA [32] was modified by the introduction of three consecutive mutations G19U-A20U-C21A, and this mutant was designated SsrASmpB.

In summary, the outcome of selection can be the consequence of two competing processes – selection for enhanced transmission through females and selection for reduced modification in males, where consecutive mutations work synergistically within each class (that is, they ease the spread of future mutations of similar effect) and antagonistically between classes.

Otherwise, a common ancestor clone could be involved in the accumulation of consecutive mutations in the CD86+ fraction.

AW performed cloning of human 5-HT3A receptor subunit and APBB1 into pGEMHE vector and made a quintuple mutant (5 consecutive mutations) in human 5-HT3A subunit.

Two of these mutations showed the germ line sequence, however they could well result from consecutive mutations as these bases are cytidines located within an RCY AID hotspot motif.

20 From a genetic point of view, carcinogenesis is characterized by the accumulation of multiple, consecutive mutations in oncogenes and oncosuppressor genes, starting the adenoma-carcinoma sequence at the level of the colonic mucosa.

However, with the consecutive coevolving mutation AP2V in the substrate, this correlation does not increase significantly yet decreases slightly in the second slowest mode.

Biopsy specimens fresh frozen from different parts of the colon and rectum, together with blood samples, were obtained from 55 consecutive LS mutation carriers who underwent regular colonoscopy screening or colectomy at two Finnish hospitals during 10/2011 5/2013 (Table  1).

Regions having at least three consecutive homozygous mutations per 200 bp were defined as mutational hotspots.