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The downstream protein of TRAF2/3 can activate consecutive initiation of MEK4 and MEK7, resulting in the activation of stress-activated protein kinases JNK1/2 [ 29].
The mechanism of HDACi activity is remodelling of chromatin through a modification of histone molecules, with consecutive initiation of cell differentiation, cell-cycle arrest and induction of apoptosis.
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The kinetic model predicts the experimental evolution of reaction products with time on stream, which follows three consecutive periods: initiation (where olefin production increases), a period of maximum olefin production and a period in which this production decreases.
The messenger RNA of the intronless CEBPA gene is translated into distinct protein isoforms through the usage of consecutive translation initiation sites.
This measure assessed the number of consecutive days from initiation of the index antipsychotic to the start of the first medication gap larger than 30 consecutive days during the first year following initiation.
Fibrinogen is a key protein in the new 'cell-based' model of haemostasis that involves four consecutive overlapping stages (initiation, amplification, propagation and stabilisation), in which the conversion of fibrinogen to a covalently linked fibrin network is the final stage [ 11, 12].
AKI was defined as an increase in serum creatinine of 0.3 mg/dL or a 1.5 to 2 times increase from baseline on at least 2 consecutive days after the initiation of vancomycin.
Step period is the time for one complete cycle (initiation of consecutive stance phases) and is divided into stance duration and swing duration.
We assumed that the patients received consecutive treatment from the initiation of the statin therapy until the end of the last prescription, because the patients were monitored regularly.
A distinctive feature of the intronless single C/EBPβ transcript is that alternative translation initiation at consecutive in-frame start sites may generate three protein isoforms with different N-termini that display activator and repressor functions (Descombes and Schibler, 1991; Calkhoven et al, 2000).
Outpatients with T2DM being treated with OADs alone, OADs combined with insulin, or OADs combined with GLP-1 receptor agonists were eligible to participate in this study if they were at least 18 years of age, had at least one previous outpatient medical record pertaining to diabetes, and had resided within a local area for at least 6 consecutive months prior to initiation of the study.
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