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Strengths of the present study include the performance of three tests for coronary angiography in all patients, the consecutive inclusion of patients, the prospectively applied protocol of patient acceptance measurement, and the intention-to-diagnose design.
However, we maintained consecutive inclusion for MDR TB patients.
Consecutive inclusion of patients seen in consultation considered as depressed by the physician.
Consecutive inclusion will enable training in small groups between 2 and 4 participants.
Consecutive inclusion of diagnostic-naive patients suspected of suffering from obstructive airway disease.
Patients were included prospectively by using consecutive inclusion during January 2010 December 2011 at each site.
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If consecutive inclusions were not feasible (eg, owing to administrative constraints in a busy clinic setting), investigators were authorised to space the inclusions (eg, one per every two to three patients), until their recruitment target was achieved.
We intend to contact physicians at least on a monthly basis, via email, telephone or regular mail, as well as use occasional motivational gifts to remind them of this trial and encourage consecutive inclusions.
Our population of RA patients, issued from consecutive inclusions, did not display differences with other studies based on criteria known to modulate EPC levels -- such as age (mean of 53 to 59 years) and frequency of use of methotrexate or low doses of corticosteroids -- or on the choice to exclude patients with previous cardiovascular events [ 25- 27].
One limitation of the study is the non-consecutive inclusion (depending on available laboratory resources) of a relatively small study population, especially at the last timepoint (T4), and the demographic differences between patients and healthy subjects.
There is no reason to assume that this non-consecutive inclusion has influenced our psychometrical findings.
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CEO of Professional Science Editing for Scientists @ prosciediting.com