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As a general rule, each consecutive exploration stage is more expensive due to the progressively more drill- and study-intensive nature of the work required, in particular after discovery of a potentially economic mineral deposit.
In consecutive exploration sessions the animal was placed in different environments, some of which the rat had not previously experienced.
19, 20 Consecutive exploration of molecules with an hydroxylated adamantyl group led to saxagliptin, that is characterized by a high in vitro and in vivo potency, good oral bioavailability (F = 75%), good duration of action (t 1/2 = 2.1 hours) and no CYP3A4 inhibition.
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Further exploration of inherent consecutive kinetic resolutions to the desymmetrization afforded 1 of >98% op in 74% chemical yield.
Data from 139 MAA SPECT/CT scintigraphic explorations involving 103 consecutive patients (79 men and 24 women) undergoing Y-microsphere therapy were analysed retrospectively.
A few years later, the Imager for magnetopause-to-Aurora Global Exploration (IMAGE) mission produced consecutive images of the terrestrial plasmasphere from the aerial view (Sandel et al., 2000; Burch et al., 2001).
More specifically, it aims to ensure both product and service components and their characteristics are continuously discussed in three consecutive front-end of innovation levels; exploration, ideation and definition.
For instance, diffuse oozing with no identifiable surgical site of bleeding was present in 42 of 191 consecutive CPB patients (22%) undergoing re-exploration for excessive blood loss.
EEG recordings were collected during a 3 hr-session of free exploration which was repeated on 5 consecutive days.
However, the essence of Systems Engineering requires repetitive integration of many viewpoints in order to find feasible designs and to make good architectural decisions, e.g., in each mapping between consecutive levels of abstraction and in each design space exploration.
Observational studies at IDEAL exploration stage (2b) should collect data for consecutive patients from multiple surgeons, including key case mix characteristics that are likely to influence outcome.
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