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Because of the risk of selection bias we repeated the study using consecutive enrolment of malaria patients and were able to confirm the results in a total of 49 DAT-positive and 183 DAT-negative patients.
By including a randomization module in a large inclusive clinical registry with unselected consecutive enrolment, the advantages of a prospective randomized trial can be combined with the strengths of a large-scale all-comers clinical registry.
Yes: when the authors report random patient sampling or consecutive enrolment.
We conducted consecutive enrolment until the desired sample size was achieved.
All participating centres agreed to consecutive enrolment of all patients with AF to minimize patient selection bias.
The use of consecutive enrolment for the psychometric evaluation ensured that the MyPOS was validated in a broadly clinically representative group.
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We conducted a prospective cohort study with consecutive patient enrolment in a large university hospital in Leipzig, Germany.
This approximates to 3 months of consecutive patient enrolment; our timeline was extended to ensure appropriate power for comparisons.
Although we aim for consecutive patient enrolment at each centre, we understand that this is often not feasible due to the high patient volume and workload of doctors.
Despite our careful design, we cannot exclude a selection bias at the patient level, possibly due to non-adherence to the rules of consecutive patient enrolment on the side of the physicians.
Participants are allocated to groups in a 1 1 1 ratio in consecutive order after enrolment by the research assistant.
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