In dose response studies, animals received three consecutive, daily oral treatments of EE (0.01 to 300 μg/kg) or TAM (3 to 3000 μg/kg b.w).. Animals were sacrificed 72 hrs after the initial dose.
There have been few studies however exploring this dose response relationship for single dose clodronate, the majority of which have involved consecutive daily clodronate infusions rather than single dose comparisons (Adami et al, 1987; Urwin et al, 1987; Bonjour et al, 1988; Kanis et al, 1990).
More detailed analysis with homogeneous groups of mice with transplanted SL2 lymphoma in DBA/2 mice showed a dose response effect in the dose range of 5,000 200,000 IU IL-2 given on five consecutive days [ 12].
Another thing: pharmaceutical researchers are often looking at something they call "the dose response".
The results are only in male rats, the incidence numbers were very small, and there's no clear dose response.
Most drugs have what's called a dose response function: You take a bigger dose, you get a bigger effect.
A clear inocula dose response was noted.
The estimated relative bioavailability of piperaquine increased by 25.3% for each consecutive dose.
Among these latter patients, 60.6% (20/33) achieved ASAS20 and 44.7% (17/38) achieved ASAS40 responses following ≥2 consecutive doses of golimumab 100 mg.
Among patients who increased golimumab from 50 to 100 mg, 60.6% (20/33) and 44.7% (17/38) achieved ASAS20/ASAS40 responses, respectively, following ≥2 consecutive doses of golimumab 100 mg.
In Experiment 1, a total of 46 heifers were presynchronized using two consecutive doses of PGF2α 12 days apart.
