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Based on our results, for 5 mg donepezil, a monthly daily compliance less than 90% or two consecutive dosage omissions were regarded as therapeutically relevant non-compliance.
For 10 mg donepezil we regarded a monthly daily compliance of less than 80% or three consecutive dosage omissions as a trigger of therapeutically relevant non-compliance.
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Rabbits received two consecutive dosages of midazolam for 30 min: 0.3 mg kg−1 h−1 (MID1 group) and 3 mg kg−1 h−1 (MID2 group).
Rabbits received equivalent normal saline (Control) and two consecutive dosages of midazolam: 0.3 mg kg−1 h−1 (MID1) and 3 mg kg−1 h−1 (MID2) (T2).
To induce MI, ISO was subcutaneously injected into the rats for two consecutive days at a dosage of 85 mg/kg/day.
For this study, the endpoint for clinical intervention was when any reduction in systolic BP was observed between baseline and a minimum of two consecutive visits under any dosage regimen.
The greatest cost savings were obtained by switching patients' PPI therapy to the least expensive PPI and also stepping patients down to a maintenance dose after 3 consecutive months at maximum therapeutic dosage (Scenario 4).
The greatest cost savings were obtained by switching patients' PPI therapy to the least expensive PPI and also stepping patients down to maintenance dose after 3 consecutive months at maximum therapeutic dosage (Scenario 4: 46% reduction).
The study medication, haloperidol 1 mg or identical placebo tablets, will be given orally to participants twice daily at 12 pm and 8 pm for a maximum of seven consecutive days (14 treatment dosages) on top of standardised care based on the implemented VMS program 'Vulnerable elderly'.
Dosage includes three consecutive single administrations of paracetamol (1500 mg) in the same individual, with enough washout in between administrations.
Methylprednisolone (MPD) treatment served as positive control drug was given i.p. at 20 mg/kg dosage for three consecutive days from day 8 to day 10 post-immunization.
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