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The latter was insufficient at some point of tumour growth resulting in critical shortage of oxygen and nutrients and consecutive development of necrosis.
The above results demonstrate that, a consecutive development of these kinds of peptide nanocomplexes may exemplify their uniqueness in biomedical applications as useful molecular-level devices.
In another two patients, chemotherapy was stopped after 1.66 cycles because of malignant biliary obstruction with consecutive development of an intrahepatic abscess and a cholangitis, respectively.
2 Regionally, the application of rhTNF-α yields an endothelial damage of tumor vessels with destruction of microcirculation and consecutive development of tumor necrosis.
Infection with Cp. abortus has hitherto exclusively been reported in pregnant women, beginning as an influenzalike illness with consecutive development of thrombocytopenia and coagulopathy, usually resulting in fetal death (4, 5 ).
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Furthermore, the findings from the trial are crucial for consecutive clinical development of H-1PV for glioblastoma and other tumor entities.
The repeated courses of antibiotics played a significant part – excessive use of antibiotics is responsible for the destruction of the normal intestinal microbial flora, with the consecutive selection and development of resistant strains of pathogens.
Although a progressive increase in tumour volume (Figure 7B) was observed in the control groups, a 4 Gy irradiation during five consecutive days stabilized the development of the tumour up to 5 weeks which then started to develop again.
Both were accepted within days of each other and published in consecutive issues in 1992.The development of functional MRI mirrors some of the key points that propelled the early development of MRI in the 1970s the involvement of visionary scientists, strong competition between research teams, and a willingness to challenge accepted notions in the field.
Note: Derive mice from consecutive litters and analyze development of tumors and metastases until the two cohorts reach the indicated numbers.
By contrast, the CRF1/CRF2 receptor antagonist, astressin-B injected ip at 5 µg/mouse once a day for 5 consecutive days resulted in the development of dark pigment on the initially pink alopecic skin within 3 days after the last injection in 4 months old male CRF-OE mice (Fig. 1B).
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