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Each patient participated in 20 consecutive assessment sessions.
A consecutive assessment of all adult patients with suspected infection over a 3-month period in 2011.
Treatment tapering: If DAS28-ESR was <2.6 at two consecutive assessment visits 12 weeks apart, TCZ was discontinued at the second assessment visit (TCZ-free remission).
Between weeks 52 and 104, open-label treatment was adapted based on response every 12 weeks, and patients continued the study in one of four treat-to-target strategies (see online supplementary figure S1): Treatment tapering: If DAS28-ESR was <2.6 at two consecutive assessment visits 12 weeks apart, TCZ was discontinued at the second assessment visit (TCZ-free remission).
If DAS28-ESR was <2.6 over two consecutive assessment visits after discontinuation of TCZ, for patients on an open-label csDMARD, the added csDMARD was stopped; for patients without added csDMARDs, the blinded oral treatment was stopped, and drug-free remission was achieved.
When no contact has been made for 3 consecutive assessment periods (for a total of 9 months) and attempts made for contact through phone calls, emails, and contact with care providers including family members, are not successful, the patient is considered to be withdrawn.
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No patients had a reduction of creatinine clearance to <40 ml/min at two consecutive assessments.
A minimum gap of two days was left between consecutive assessments to minimise carryover effects.
Synovitis did not have to be present in the same joint on consecutive assessments.
Longitudinal incidence or change quality indicators require measures of patient status at two consecutive assessments.
Complete or partial response had to be confirmed on two consecutive assessments 4 weeks apart.
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