The connectivity mapping is then carried out on all the perturbation signatures and the original one, and a data matrix of the connections' significance index can be compiled, by the summation of the therapeutic instances per list, thus incorporating all the results.
It is about connection and significance — about the way the past becomes the future, the contingent the inevitable, the spandrel the success, the success the tragedy.
Moreover, we addressed the connection of statistical significance of associate analysis and biological significance via a priori candidate genes and a gene network, the combination of which has not been widely explored.
But while undeniably goaded by such temporal serendipity, I do see a connection of deeper significance.
The genes which have significance connection between the biological response pattern (GI50) and the baseline gene expression, though may not be directly linked to the primary drug targets, they should be close to the pathway where the mechanism of action taking place.
No changes in intrahemispheric connections met statistical significance.
Although a little information is provided about the anatomical connections and functional significance of the reuniens nucleus, but the manuscript would be improved if a little more information along these lines was provided.
The continuous liquid-to-solid transition near Tg, the glass transition, has a profound significance in connection with classical applications of glasses.
It is also unclear whether actin is actively exchanged between the nucleus and the cytoplasm, and whether this connection has any functional significance for the cell.
