In our discussion we mainly focused on the meiotic/mitotic spindle connections of the identified by us proteins.
In the next step the robust connections of the identified network are further analyzed by bootstrapping the experimental data set.
IPA (Ingenuity Systems, 2012 release), a software leveraging a manually reviewed repository of biological interactions and functional annotations was used to analyze the signalling pathways, cellular location, function and, network connections of the identified genes [ 28].
In addition, we used the Ingenuity Pathway Analysis (IPA) to determine network of connections between the identified apoptosis-regulating miRNAs of reported relevance to cardiovascular disease.
PARADIGM [ 22] is another approach aiming at the integration of heterogeneous data and, additionally, at the inference of connections among the identified molecules.
We manually evaluate through scientific literature the connection of PE with the identified metabolic pathways and diseases.
This, combined with the 4 unsaturations implied by the molecular formula, indicated a bicyclic structure for 9. Connection of the structural units identified so far was provided by the HMBC experiment (Table 2 and Figure S2a).
Somogyi, P., Kisvárday, Z. F., Martin, K. A. & Whitteridge, D. Synaptic connections of morphologically identified and physiologically characterized large basket cells in the striate cortex of cat.
Parameters significant to the performance of the connection are identified through experimental results and a design procedure is developed.
In order to better compare the inferred connectivity maps evaluated by means of TE, JE and CC, Figure 7A indicates the number of connections commonly identified on the experimental data considering the methods between pairs.
