Thus, dominance over off-state stability is not an intrinsic property of a single strongly connected motif but rather depends on the context given by the specific composition of the feedback family.
Connected motifs were categorized by conventional graph theoretical means, i.e. ordered by their number of nodes N into dyads (N = 2; for directed graphs there are 2 distinct connected dyads: asymmetric and mutual), triads (N = 3; for directed graphs there are in total 16 triads but only 13 are connected), et cetera.
A directed graph connecting a motif to other motifs, which are substrings of itself, is the preferred visual representation as seen in Figures 4 and 5.
BshC consists of 539 amino acid residues with a core Rossmann fold domain, two connecting peptide motifs (CP1 and CP2), and an α-helical coiled-coil domain.
The structure reveals that BshC contains a core Rossmann fold with connecting peptide motifs (CP1 and CP2) and a unique α-helical coiled-coil domain that facilitates dimerization.
In our model, hundreds of motif-binding domains in higher eukaryotic proteins connect simple motif specificities with useful functions to create a large functional motif space.
The second class of motifs, the strongly connected subgraph motifs, are prevalent in the World-Wide web structure [20] and are indicative of reciprocal links between pages.
IB-GGGG motifs were linked by long-range couplings across the ring, while intrasubunit couplings connected the motif to the conserved cytoplasmic loop and adjacent segments.
A single O−H···O=C connected catemer motif results in four fundamentally different chain geometries.
All polymorphs contain the same O H···O=C connected catemer motif, but the geometry of the resulting H-bonded chain is different in each form.
Essentially, the procedure followed by all such approaches is to identify differentially expressed genes, identify motifs that are overrepresented in these genes and then connect these motifs back to miRNAs.
