To explain French music's other alien visitor, Olivier Messiaen, look perhaps for connecting strands of Berliozian DNA.
These disulfide bonds connect strands a and b, strands c and g, and loop d d′ to strand g, respectively (Fig. 2b).
In fact, NAG303 forms H-bonds with D390 and D391 of the neighboring loop and buries approximately 150 Å2 of surface area on the two loops that connect strands a a′ and strands e f (Fig. 3a).
However, the S-shaped double loop connecting strands III and IV is fixed closer to the β-sheet and projects its His172 side-chain further into the rather hydrophobic active-site cleft, defining the S3 and the S1-pockets and separating them from each other to a larger extent than is observed in other MMPs.
Crystallographic analysis of the wild-type enzyme at 1.2-Å resolution reveals a hydrogen bonding network, including a buried and well-ordered water molecule connecting strands βE to βF, a common feature found in 16 of 21 known three-dimensional structures of the family.
Nevertheless, one protein region that consistently binds RNA is located at the junction between strand β1 and helix α1 and the turn connecting strands β3 and β4.
To report the intraoperative optical coherence tomography findings in idiopathic epiretinal membrane (ERM) with connecting strands and to describe the postoperative outcomes.A retrospective, case series study within a prospective observational intraoperative optical coherence tomography imaging study was performed.
Epiretinal membranes with connecting strands were characterized on preoperative spectral domain optical coherence tomography images and assessed against corresponding intraoperative (after internal limiting membrane [ILM] peeling) and postoperative spectral domain optical coherence tomography images.Eleven locations of the connecting strands in 7 eyes were studied.
The corresponding loop in Cass2, connecting strands β7 and β8, is relatively short (136 140) and unlikely to participate in a similar interaction.
