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Neural circuitry within M1 is modified following repetitive transcranial magnetic stimulation (TMS) applied directly over M1 [7], [7] or to anatomically connected loci such as the premotor cortex [8].
The overlap between the genes present within the MEN and the highly connected loci, identified by Dapple was established.
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Edges connect loci that are in LD with each other and SNPs in a chromosome are modeled using a Markov graph.
As anticipated, many interactions connected genomic loci of well known protein complexes such as the ribosome (8 links) or the bacterial flagellum (5 links).
For this, we applied a filtering algorithm (which involves the comparison with randomized networks) to enrich highly connected genomic loci (Figure 2, Table S2).
A growing body of evidence supports the strategy of connecting genomic loci and coding genes using a many-to-many mapping and considering long-distance cis-regulation.
The edges connecting different loci were weighted by the number of taxa shared between them, divided by the total number of taxa.
Overall, these observations suggest that the identification of a sequence variant should not be the logical end point that automatically connects the locus that harbors it with a phenotype, but rather a beginning of a set of experimental procedures to unravel the effects of the variant.
Jha and Shankar 2011 4 QlicRice http://nabg.iasri.res.in:8080/qlic-rice/ A database of 974 abiotic stress-related QTLs connected with 460 locus IDs, with their physical and genetic data, which can be easily queried.
DAPPLE aims to evaluate whether genes in association loci are significantly connected by PPI, where the association loci are typically defined by the standard single marker analysis of a GWAS dataset for a complex disease/trait.
Syntenic loci are connected by gray lines between the genomes.
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