Sentence examples for connected compounds from inspiring English sources

For example, excluding highly connected compounds to avoid currency compounds may also exclude compounds that play a significant role in pathways (e.g., pyruvate).

Araki et al. refers to a paper by Barabasi and Oltvai [38], which suggests that highly connected compounds that are not currency metabolites are critical in linking together many compounds in the metabolic network.

By including these highly connected compounds as first intermediates, the M-path algorithm can shorten the number of reaction steps needed to reach the target compound and improve the performance of the search.

In Croes et al. [31], the weight of compound vertices is set equal to the degree of the compound in the network, biasing the search against going through highly connected compounds.

This is a simple way to exclude spurious links via highly connected compounds, such as water or adenosine triphosphate.

The second policy ('compound degree weight') penalizes highly connected compounds by assigning to each compound a weight equal to its degree, whilst setting to each reaction a weight of one.

Many approaches identify highly connected compound nodes in the graph, or hub compounds, which appear in many different reactions.

The purpose is to enlarge weight differences between highly and weakly connected compound nodes.

Predict interacting compound protein pairs by connecting compounds and proteins which are closer than a threshold in the pharmacological space.

Predict potential compound protein interactions by connecting compounds and proteins which are closer than a threshold in the unified feature space, following the spirit of the nearest neighbor.

By comparing the gene expression signatures of drugs, diseased samples, and mutants, cMap was able to connect compounds, diseases, and genes through gene expression profiles.