Next, optical sectioning was used in conjunction with structured illumination microscopy to more precisely delineate the intracellular expression of CXCR7.
In this study, pramlintide's effect was evident when used in conjunction with structured LSI, which was important to establish because nonpharmacological treatments are a cornerstone of weight management and official treatment guidelines recommend that pharmacological agents be tested in combination with LSI (13, 14).
Until now, DMD was used to perform simulations of simplified protein models in conjunction with structure-based force fields.
Rational design in conjunction with structure-based design led initially to the identification of anthranilic acid 5, an mPGES-1 inhibitor with micromolar HWB potency.
Results from high-throughput screening efforts have led, in conjunction with structure-based drug design, to the identification of highly potent and selective small molecule IRAK4 inhibitors from many diverse chemical series.
Sediment biogeochemistry was analysed in conjunction with structure and diversity of the nematode community and differences were tested between study areas, water depths (700 m vs 1000 m), stations, and sediment layers.
Second, studies of naturally occurring loss-of-function mutations in MC4R from obese subjects [23] [27], in conjunction with structure-function studies [28], [29], have identified several key regions of the receptor that are required for binding of the endogenous ligand, α-MSH.
Ad hoc thresholds are often used in conjunction with structure learning algorithms to determine significant associations.
Advances in understanding of the OGA reaction mechanism [ 18], in conjunction with structures of bacterial OGAs [ 19, 20], have informed the development of a number of highly potent and selective inhibitors for hOGA [ 21].
This and various other methods that have been devised to identify functional residues in proteins, such as residue interaction graphs (Amitai et al. 2004) or statistical methods reviewed by Ahola et al. (2004) could reasonably be used in conjunction with structure-based alignment methods to determine reasonable alignments based on functional considerations.
Clients did not seem to discuss the barriers to increasing physical activity (e.g. cost, time) that are normally raised in conjunction with promoting structured exercise programmes, which was an important objective of the intervention.
