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Thus, this conjugation modality often gives multiple ADC species with variable DARs and conjugation sites.
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Hence, cyclic RGD conjugation makes the GNP-based radiosensitizer tumor targeting, offering a new modality for enhancing radiotherapeutic efficacy.
Addition of metal-binding modalities to proteins has been accomplished primarily through chemical conjugation.
The dual-modality molecular probe design also possesses three amino groups for potential conjugation with multiple copies of targeting molecules, thereby providing multivalent effect to the construct for better specific binding to the biological target of interest.
However, this modality still has room for improvement to achieve better DAR and heterogeneity control: the above-mentioned simple cysteine conjugation can give a DAR distribution raging from 0 and 8. Junutula and co-workers introduced two new cysteine residues (one per heavy chain) for selective antibody attachment (Junutula et al., 2008).
After conjugation of folic acid molecules, the obtained BSA-Au nanocomplexes showed highly selective targeting for MGC803 cells and dual-modality dark-field and fluorescence imaging.
"Ineluctable modality".
Phase conjugation.
"Ineluctable modality of the".
Verb conjugation became muddled.
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