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Meanwhile, PEG conjugation increases the micelle's solubility, biocompatibility, provides stealth against the reticuloendothelial system (RES) and improves circulation time.
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Decreased UGT1A1 activity reduces bilirubin conjugation and increases the circulating unconjugated bilirubin concentration.
Fig. 7 Cellular uptake as a function of particle surface modification a folic acid conjugation increases nanoparticle endocytosis in Y-79 cells.
Results indicate that EGF conjugation increased transfection efficiency the most when conjugated to the outer surface of polyplexes, with minimal disruption to DNA packaging and maximal accessibility to receptors.
NK cells formed few conjugates with the untransfected RMA cells, and the conjugation increased when RMA cells expressed the standard H60a (Fig. 2).
These three conjugation reactions increase the molecular weight and water solubility of the compound, in addition to adding a negative charge to the molecule.
These results suggested that integrating icariin into scaffold by chemical conjugation will increase the quality of formed cartilage, and may decrease the risks of excessive release, therefore is valuable in cartilage tissue engineering.
In [5], it was reported that the conjugation significantly increased the detection limit of ricin to 100 pg/mL.
Folic acid conjugation also increased the cytotoxicity of the Dox-conjugated hairpin toward 4T1 cells consistent with both improved cell uptake and efficient Dox release.
Phase II metabolism often succeeds phase I metabolism and yields mainly more hydrophilic metabolites, mostly by conjugation, thereby increasing the water solubility of lipophilic compounds.
Moreover, the conjugation of the polymers increases the number of unstructured domains as expected for the conjugation of a polymer with a random coil conformation in a collapsed state.
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