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For example, proteins with unique chemical handles for precise conjugation can be generated to enable next generation antibody-drug conjugate therapeutics.
Our studies show that folic acid conjugation can be used to improve uptake for DNA hairpin conjugates into breast cancer cells, and this is expected to concomitantly reduce systemic toxicities.
Moreover, the conjugation can be incorporated into an integration by parts formula.
Therefore conclusively conjugation can be a better option for the delivery of natural bio-actives through dendrimers.
New covalent Al-carbon bonds are formed along the polymer backbone; the chain geometry is deeply modified and the π electron conjugation can be dramatically reduced.
By applying PEG moiety in the side chain of the linker-drug, the organic solvent used in the conjugation can be reduced.
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Our work thus highlights that site-selective polymer conjugation, which is possible using protein engineering alongside common conjugation approaches, can be used to fine-tune functional properties of polymer protein bioconjugates.
Nevertheless, compatible isogamous gametes in fungi do not necessarily exhibit identical roles in cell fusion, and in particular the initiation of conjugation structures can be a behavior specific to only one mating type (Day, 1976).
The main function of the micronucleus becomes obvious only during sexual reproduction, the conjugation, which can be induced by mixing ciliate cells of different mating types.
Such improvement in conjugation length can be utilized to enhance the photovoltaic properties of polymeric solar cell.
Another advantage of this LLQG-specific bacterial transglutaminase is that conjugation sites can be flexibly laid by inserting this short peptide motif within the antibody structure.
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