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The antibody approach was widely utilized as the targeting moiety either directly conjugated with high payload contrast agent or elegantly applied in multiple steps to pre-label the tumor as a biotin-labeled antibody [29].
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Moreover, we only measured the amount of total HNE in circulation, which was mostly conjugated with high-molecular-weight inhibitors, instead of assessing directly the HNE activity.
The general procedure for the liquid-phase synthesis of oligonucleotides conjugated with high-molecular mass PEGs can be schematized by the flow-chart.
We measured total NNAL (free plus conjugated) with high-performance liquid chromatography coupled with electrospray-ionization tandem mass spelectrospray-ionization tandem has been described in Xia and Bernert (2010; LOD 0.6 pg/mass
Understanding these structural and steric effects on their drug release characteristics is crucial for the design of dendrimer conjugates with high efficacy.
Melittin PEI conjugates with high lytic activities at endosomal pH were then incorporated into EGF receptor-targeted and polyethylene glycol-shielded polyplexes.
In Figure 5, zeta potential-pH profiles of these QR conjugates with high (-R1) or low (-R2) amounts of diamino-PEG are reported.
Hapten concentration was pivotal for the preparation of BSA conjugates with high hapten density.
Thus, MorHap-BSA conjugates with low hapten densities were more soluble in aqueous environment than MorHap-BSA conjugates with high hapten densities.
Thus, despite the substantial increase in cell delivery potential afforded by such dendrimeric peptide constructs, peptide conjugates with high Arg content must be used with caution in therapeutic development until the sources of these toxicities (both cellular and in vivo) can be controlled.
However, the BH3 analog that can be conjugated with Mcl-1 with high affinity and high specificity has not been developed yet 35383538
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