Seventeen conjugates between the single-chain variable fragment scFv of mAbD1.3 and an environment-sensitive fluorophore were constructed.
Eight conjugates between a single chain variable fragment of mAb4E11 and an environment-sensitive fluorophore were constructed.
A series of novel amide and thioester conjugates between Danshensu and cysteine derivatives have been designed and synthesized based on the strategy of "medicinal chemical hybridization".
To further investigate, the objectives of the current study were to (1) synthesize and characterize stable amide and cleavable hydrazone conjugates between mPEG and carbon-5 on the chroman moiety of T3, and (2) examine the cytotoxicity of the newly synthesized mPEG conjugates against breast (MCF-7 and MDA-MB-231) and pancreatic (BxPC-3 and PANC-1) cancer cells.
Chemical conjugates between sodium cellulose sulfate (CS), displaying contraceptive and HIV-entry inhibiting properties, and nucleoside reverse transcriptase inhibitors (NRTIs) (3′-azido-2′,3′-dideoxythymidine (AZT), 3′-fluoro-2′,3′-dideoxythymidine (FLT), or 2′,3′-dideoxy-3′-thiacytidine (3TC)) were designed to simultaneously provide contraceptive and anti-HIV activity.
To identify the mode of viral transmission in the HTLV-1 VS we examined the ultrastructure of the VS using electron tomography of immunostained conjugates formed between CD4+ T cells from HTLV-1-infected individuals and conjugates between MS9 cells (a chronically HTLV-1-infected cell line) and Jurkat cells.
For the purpose of this study, immune synapses were considered inhibitory when conjugates between HLA-Cw4 or HLA-Cw15-expressing target cells and NK cells displayed clustering of cyt42/43-reactive cyt42/43-reactive
Many plasmids conjugate between different bacteria, especially related ones, leading to intra- and inter-specific dissemination of plasmid-specific genes, for instance, antibiotic resistance genes.
Fluorescence in situ hybridization coupled with immunofluorescence: mating Tetrahymena cells conjugating between 2 and 4 hr were fixed in partial Schaudin's fixative as described (Madireddi et al., 1994) (Wenkert and Allis, 1984), and dropped on slides.
