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We identified 115 genes that showed differential expression between comparison groups in the two studies (Fig. 4, Additional file 1: Table S1), and they showed significant congruence of expression (Binomial test, p = 2.8 * 10−7).
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The high congruence of the expression profiles of Vrn-A1 in spring Norstar and spring Manitou and the expression profiles of vrn-A1 gene in winter Norstar and winter Manitou indicates that the genetic factors needed to regulate the transcription of Vrn-A1 and vrn-A1 genes are similar in the two genetic backgrounds.
These findings are consistent with the congruence of immunohistochemical expression patterns for CBS and ADRP in the CA (Fig. 3) of the co-morbid pigs.
The congruence of the expression rates of the examined tumor biological factors indicates a causal line of suppressor, proliferation and mitosis markers and growth factor receptors.
The congruence between patterns of expression behavior in hybrids compared to the interspecies comparison suggests a model of semidominance where hybrids have an intermediate level of expression compared to the two parental species Our analysis of hybrid females relative to the two parental species provides key insight into the process of oogenesis in hybrid females and the two parental species.
Our aim is to evaluate the congruence of publicly available expression datasets.
This core set of genes shows a significant congruence in the direction of expression between the two studies (i.e. elevated expression in the proactive coping style line (LSB) is similarly elevated in the pharmacologically induced proactive coping style (anxiolytic-treated fish [ 24])), which suggests these genes are not artifacts of our selection procedure or drug effects.
The congruence of the examined factors' expression rates indicates a causal line of suppressor, proliferation, and mitosis markers, and growth factor receptors.
Based on the congruence of chronic inflammation, continuous expression of proinflammatory cytokines and recruitment of immune cells, where SAG-UPS feature prominently, Chang and Ding hypothesized that SAG-UPS switches the cells between immune-overactivation and pro-tumorigenesis.
Furthermore, in nearly all of the cases where CgrA functions as an activator or a repressor of expression there is congruence in whether the same set of genes undergo an increase or a decrease in expression during development of cysts in wild type cells (Additional file 3: Table S3).
Similarly, the generally high level of congruence of detection of significantly different expression, also suggests that robust measurement of differential gene expression is possible with these microarrays.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com