This analysis reveals the temporal and spatial evolution of a GBM tumour, defining the origins of the lethal sub-clone from a sub-clone in the primary tumour and the associated macro-evolutionary genomic events dominating the disease at recurrence, confounding treatment success.
Metastatic melanomas feature significant genetic and phenotypic heterogeneity, with the potential to confound the success of many therapies.
On the other hand, they argued that Seddon's [ 7] restructuring of the DeLone and McLean [ 3] model into two partial causal models could confound the success model and deviate from the original intention of their model.
In fact, the likelihood that key biomarkers may exist in blood mainly bound to albumin has potentially confounded the success of many plasma or serum-based biomarker discovery studies, since albumin and other abundant protein depletion strategies have been implemented in an effort to reduce the large dynamic range of these fluids [ 16].
Over the past 12 months, Miku has enjoyed remarkable crossover success, confounding David Letterman when she recently appeared on his show, opening for Lady Gaga's ARTPOP Ball tour earlier this year, and headlining live shows in New York and Los Angeles.
But Mr. Ghosn's success at confounding the doubters and his air of self-assurance have made him something of a hero in the popular media and turned his success into a cliché.
Both have gained much of their success from confounding what has been mainstream party thought for decades.
If success confounds him and makes the band implode, Stump could easily survive by writing big, hopeful hooks for whichever team — likely a less worried one — wants him.
Mr Johnson, a Games evangelist, has insisted the Olympo-sceptics who had been confounded by the success of London 2012 will be proved just as wrong about the legacy of the park.
— Chicago White Sox pitcher Chris Sale, to Yahoo Sports, on how his success confounds sabermetric analysts.
