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A cohort study compares patients who were exposed to patients who were not exposed, whereby all confounding needs to be controlled for numerically, however the self-controlled case series compares the number of events in periods of exposure with the number of events in periods of non-exposure in the same person.
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Nonetheless, for the comparisons to be meaningful, the levels of exposure and study design and data analysis, especially the validity of the exposure assessment and control of confounding, need to be taken into account.
This confound needs more discussion and to be offered as a viable additional explanation perhaps.
A potential confound needs consideration; that the correlation between alpha power and gait speed could be due to movement artefact.
The lack of adjustment for reproductive factors might probably exert negligible confounding effect because a confounder needs to be associated with both exposure and disease, and should not be an intermediate variable in the causal pathway [ 44].
Finally, two additional confounds need to be addressed.
As severity of hypertension will always confound need for treatment and perinatal outcomes, this must be considered for appropriate conclusions to be drawn.
Since circulating plasmalogens are decreased in a number of other clinical conditions, the effects of these potential confounds need to be addressed in future AD studies.
However, this method is subject to confounding and needs further refinement, as the authors stated themselves [53], [54].
In addition, the consistent predictability of confounding amplification needs to be further established.
In the analysis we assumed there was no strong seasonal confounding that needs to be controlled, except time trend.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com