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After all, biological variability had answered all the odds and confounding data that I observed, or at least that was what I was told to believe.
Sirt6 loss- and gain-of-function studies have generated confounding data regarding the role of this sirtuin on energy and glucose homeostasis, leaving unclear whether activation or inhibition of SIRT6 may be beneficial for the treatment of obesity and/or T2DM.
The human brain is hard enough to figure out without throwing in useless, confounding data from other animals.
While some reports contend that overall study conclusions would remain the same as the variability in a reference gene would be similar between study and control groups [13], others note that normalization to an inappropriate endogenous control may lead to misinterpretation and confounding data with qRT-PCR [7], [14], [15].
Therefore, we suggest that researchers and practitioners consider potential PAP effects on isometric strength assessment protocols and take extra care in the analyses process to avoid confounding data.
Normally in Big Blue experiments using drug-treated animals, jackpot mutations are disregarded as confounding data resulting from clonal expansion in a subset of cells created during tissue development in vivo.
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In addition, construction of a phylogenetic tree of cancer subclones and their evolution allows eliminating confounding data-points generated by genetic instability and by admixture of cancer subclones which represent evolutionary dead ends.
This confounds data interpretation and limits reliable determinations of the nature and extent of additivity.
Generally, false negative effects are unlikely to confound data processing.
First, they have many different uncontrolled variables that can confound data analysis and interpretation.
These recombination events are presumably too rare to confound data interpretation, unless they lead to dominant effects such as tumorigenesis.
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