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However, in the absence of mutant strains, similar to those used in Drosophila [ 25], it is difficult to quantify dosage compensation in the germline because of extensive sex-specific expression in these tissues, and the confounding consequences of germline X-inactivation.
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Figure 4B also illustrates a confounding consequence of the decaying noncorrected oxygen consumption rate; if the mean rates from different measurement period lengths are calculated (stars), an artifact is generated.
Unfortunately, many of the reports fail to adequately adjust for the confounding consequence that hypoxic episodes and hypercapnoea may have on the patient's neurological status.
We used female mice to remain consistent with our many previous studies based on the environmental enrichment and exercise paradigms that had to be carried out in females in order to avoid confounding stressful consequences of territorial behavior that is more prominent in male mice than in females (Kempermann & Gage 1999; Kempermann et al. 1997, 2002).
The consequence of this confounding issue would be to create a misimpression that the expression pattern of down-regulation of the X chromosome occurs earlier during the mitotic stage of spermatogenesis [ 31].
We put together non-smokers and ex-smoker in the reference groups for the effect of current smoking with the potential consequence of confounding.
An alternative explanation is that higher serum highly sensitive CRP is a biomarker for lower lung function and that the apparent associations between coagulation pathway activity and lung function that we have observed are in part a consequence of confounding.
This complex relationship is due in part to the fact that obesity could be a cause, consequence, or confounding factor of OSA [ 14].
There is no obvious mechanistic explanation for the lack of effect in severe anemia, although the fact that this interaction did not persist in a fully adjusted multivariate model suggests that it could be a consequence of confounding.
Together, this approach allowed us to study epigenetic mechanisms and their functional consequences without the confounding background of organ hypoxia and apoptosis in explanted hearts of deceased patients.
The consequence of dependencies, confounding, and other "noise" is an unacceptably high false-positive rate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com