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Yet determining the specific contribution of each (enclosure size, group size and density) is a challenge because confounding between two or more of these factors is experimentally difficult to avoid.
VC scores are subject to a degree of indeterminability when there is complete confounding between two or more factors.
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Despite these differences, pulmonary findings can be confounding between the two diseases, such that biopsy is mandatory in young females with a pure cystic pattern at onset/initial presentation (Fig. 11).
These estimates do not support the hypothesis that arsenic and magnesium are highly correlated in drinking water, hence reducing concerns about confounding between these two minerals.
There was no difference in the median age, gender, DSS, smoking history, history of dust exposure, and symptoms before the start of corticosteroid therapy or duration of corticosteroid administration between the two groups (Table 2), demonstrating that the dichotomous process using the median daily dose showed no confounding factor between two groups.
These models therefore allow possible confounding between the two effects to be assessed.
Thus, the proportional difference in absolute degree of estimated confounding between the two estimates = (0.482 - 0.577 /0.577 = −16.3%.
We also carried out an analysis in which potential confounding between the two drug classes was controlled by restriction.
This enables women to be cross-classified by both their alcohol and tobacco consumption, thus permitting adequate examination of possible confounding between the two exposures.
To improve this analysis, one could potentially use a principle components analysis to adjust for the variant confounding between the two groups in a regression analysis or perform a permutation test to help adjust for unknown confounding.
Since all the included studies were observational, there remains the possibility of uncontrolled confounding between the two treatment groups and thus, there are concerns regarding the comparability of both operative arms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com