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To avoid corruption of the analysis from bad quality or confounded data, any row (probe) in the data matrix that contained a detection P value (quality control indicator) above 0.05 was discarded, as was any probe whose represented CpG site was two or fewer nucleotides from a known SNP (see Additional file 1: Figure S1) for which that SNP had a minor allele frequency above 0.05.
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This confounds data interpretation and limits reliable determinations of the nature and extent of additivity.
After all, biological variability had answered all the odds and confounding data that I observed, or at least that was what I was told to believe.
Sirt6 loss- and gain-of-function studies have generated confounding data regarding the role of this sirtuin on energy and glucose homeostasis, leaving unclear whether activation or inhibition of SIRT6 may be beneficial for the treatment of obesity and/or T2DM.
The human brain is hard enough to figure out without throwing in useless, confounding data from other animals.
Generally, false negative effects are unlikely to confound data processing.
First, they have many different uncontrolled variables that can confound data analysis and interpretation.
These recombination events are presumably too rare to confound data interpretation, unless they lead to dominant effects such as tumorigenesis.
Temperature and pressure fluctuations, both having the potential to confound data obtained, were recorded on a daily basis (Table 2).
However, the whole blood approach has the potential to confound data interpretation due to heterogeneous blood cell populations.
As in previous reports, we concomitantly deleted ddb1 + and its other known target spd1 + as not to confound data by cell cycle defects caused by stabilized Spd1 [ 22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com