Sentence examples for conformational alterations from inspiring English sources

In the induced-fit model, substrate binding is believed to induce conformational alterations in the active site to cause a new conformation for the entire enzyme.

Due to the complex interlaced architecture of fibrillar extracellular matrix, a large range of conformations is seen in native extracellular matrix and often, major conformational alterations are seen at distances along a extracellular matrix fibril of one micron or shorter [35].

Conformational alterations, induced by ribosomal-recycling factor, facilitate subunit dissociation.

However, one should bear in mind that covalent coupling of enzymes to polymers may result in conformational alterations, pharmacokinetic modifications, and a significant decrease in enzymatic activity.

Evidently, transactivation and C-terminal helicase domains of phospho-p68 exhibited dramatic conformational alterations to assist β-catenin and RX-5902 binding.

We show that mutations linked to arrhythmogenic right ventricular cardiomyopathy (K470E and R808C) cause local conformational alterations, while the overall folded structure is maintained.

Background: Conformational alteration and fibril formation of proteins have a key role in a variety of amyloid diseases.

Thus, our findings on the conformational alteration of SHP-2 in a solution interrupted system furthers our understanding of allosterism.

Within 40 ns, MD simulation time composed of the E177K mutant shows conformational alteration especially in several parts of the variant.

And the captured CO2 could be completely desorbed under 120 °C on APS/LDHs, which is a rather safe operation temperature to avoid the amine degradation or thermal conformational alteration.

A series of cis-preferential aromatic N-methyl amides was designed and synthesized, and acid-induced conformational alteration of these compounds was investigated by means of NMR measurements in solution and X-ray crystal structure analysis.