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The trimer variants were indeed stabilized in the closed conformation, with a reduced ability to undergo receptor-induced conformational changes and a decreased exposure of non-neutralizing V3-directed antibody epitopes.
Simulations and experiments identified two conformations: an open-like conformation with a small contact interface stabilized by salt bridges, and a closed-like conformation with a larger contact interface stabilized by surface-exposed hydrophobic residues.
And for intercalating amyloid-beta oligomerization, long and linear conformation with a lipophilic group was considered.
The refinement indicates a twofold helical conformation with a nearly planar (CT 2 backbone.
On the basis of simulation results, this intermediate is interpreted to represent a conformation with a denatured C-terminal repeat.
The electron microscopy and simulations show that isolated tropomyosin has an average curved conformation with a design well matched to its superhelical shape on F-actin.
Analysis of the unfolded variant by FPOP MS shows oxidative modifications consistent with the species adopting a solution conformation with a high degree of solvent accessibility.
PQcOx-T exhibits a zigzag conformation with a dihedral angle over 25° and shows an edge-on structure in pristine film.
The backbone torsion angle (φ1,ψ1,φ2,ψ2) of an azapeptide model appeared to be the β-turn conformation with a dihedral angle (−61°,131°,79°,15°).
The bistetracene takes a "face-to-face" stacked conformation with a large displacement along the short axis of the tetracene skeleton.
In order to optimize the aliphatic side chain conformation with a subsequent entropy benefit, we incorporated an oxolane ring and generated two stereo diasteromers, AMCR277A and AMCR277B.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com