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After conformation process of our XP-EHH-method that confirmed a selection signature for all three phenotypes tested, we checked if it was able to detect significant selection signatures close to previously published candidate genes of six known QTL associated with beef (TG) and dairy cattle production traits (ABCG2, Casein Cluster, DGAT1, GH1, GHR).
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Importantly, it was found that the mobile structured oligomers undergo large conformational changes to accommodate the added monomer, a clear indication of mutual conformation selection process.
b Flowchart depicting conformation sampling process.
The enhanced DOVIS software will take multiple conformations of a receptor, automatically set up multiple sets of energy grids, dock ligands into each receptor conformation, and process the results.
Our method also requires a large number of computations due to the conformation sampling process with MD simulation.
GTPases cycle between an inactive GDP-bound and an active GTP-bound conformation, a process which is regulated by the concerted action of activating guanine nucleotide exchange factors (GEFs) and inhibiting GTPase activating proteins (GAPs) [2].
The multiple conformation generation process involves the creation of a random distance matrix, which satisfies the upper and lower bound of the distance matrix of a molecule.
Although multiple spindle poles are generally resolved into a semi-clustered/pseudo-bipolar conformation, this process is nevertheless highly prone to the formation of merotelic spindle-kinetochore attachments, which can promote chromosome missegregation (Ganem et al., 2009).
The winding into nucleosomes also allows some inactive DNA to be folded away in inaccessible conformations, a process that contributes to the selectivity of gene expression.
A multimodal AFM combined with fluorescence microscopy can give valuable additional information and conformation of processes observed with the AFM.
The overall description of disposition for diverse chemicals requires that the results for conformation-dependent processes are embedded in the models for property-dependent processes.
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