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Results were consistent with previous findings from cysteine accessibility assays used to assess an inhibitor's DAT conformation preference.
In search of the molecular basis for DAT conformation preference, complexes of cocaine, benztropine, LX10 or LX11 bound to each DAT conformation were subjected to 100 ns of all-atom molecular dynamics simulation.
DNase I is a DNA endonuclease that hydrolyzes preferentially double-stranded DNA and cleaves without sequence specificity but with some DNA conformation preference [80].
> Conformation state: we use a Gaussian distribution to describe the local conformation preference of one nucleotide.
Similar(55)
The frequent occurrence of similar helical motifs suggest nature's finite and perhaps limited repertoire of RNA helical conformation preferences.
This was likely due to the very small size (collisional cross section area) differences compared to their overall larger masses, although specific conformation preferences for the molecules may have played a role as well.
Therefore, it is important to understand the basic rules governing the ring conformation preferences for individual monosaccharide blocks of the GAG molecules.
Therefore, we posit that an affinity probe based on YK5, because of its ADP-conformation preference and also its covalent modification of Hsp70, may indeed be able to affinity purify Hsp70 bound to its protein clientele.
The backbone structure (upper panels) as well as the Ramachandran plot of the conformation of the alanine residue during the entire simulation, demonstrate the conformational preference for L-alanine to adopt the αR conformation and for D-alanine to favor the αL conformation (lower panels).
The cis conformation is ∼2.5 kcal/mol less stable than the trans conformation for non-prolyl amino acids in solution, providing an estimate for the upper limit of the conformational preference of the remaining loop residues of the Pro39 mutants for the cis conformation relative to the trans conformation.
It seemed possible that the β T238A mutation might stabilize microtubules by shifting the conformational preference of unpolymerized αβ-tubulin to favor a straight er) conformation that is more compatible with the microtubule lattice.
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