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Upstream allosteric sites could switch from inactive αC-helix-out state (OFF) to the active αC-helix-in conformation (ON) [12].
A bi-specific [ 67, 68] or dual variable domain [ 69] antibody combining recognition of the two conformations of Aβ revealed from crystal structure studies, that is, extended conformation on one arm and helical conformation on the other arm, would offer intriguing dual activity that could be particularly well suited for disaggregation of β-amyloid plaque independent of effector cell engagement.
Figure 3 Influence of an undefined chiral center conformation on the inverted tetrahedral sub-layer.
However, the specific effect of Fn conformation on tumor angiogenesis is undefined.
The porphyrin dimers formed a thermally favorable face-to-face conformation on the duplex DNA.
Peptide backbones tended to adopt a β-strand conformation on incorporation into a film.
Density of controllable groups and conformation on the surface of MNCs were tuned by adjusting the APTS-to-MNCs ratio.
The effect of molecular conformation on the solid-state optical properties of the dyes is also discussed.
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In conclusion, surface-immobilized systems can provide unique insights into the effect of molecular crowding on the conformation of peptides and proteins in high-molecular-density environments, and biophysical tools are today available for measuring molecular conformation on-surface.
Therefore, as observed for glycans bound to GHs, 3, 25 the inhibitor conformation on-enzyme is not only dictated by the relative energy of the molecule itself but also by structural and electronic properties.
11 For enzymes from GH2, 21 GH26, 13 and GH47, 11 conformations of ground states adjacent to the transition state (Michaelis, glycosyl-enzyme or product complexes) provide strong evidence that mannoimidazole-type inhibitors authentically report transition-state conformation on-enzyme.
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