Sentence examples for conformation needed from inspiring English sources
PB stalls SF3B in an open conformation by acting like a wedge within a hinge, modulating SF3B's transition to the closed conformation needed to form the BS adenosine-binding pocket and stably accommodate the BS/U2 duplex.
For example, the isolated NES of Rev binds to CRM1 much more weakly than does the full-length Rev protein [61], implying that an NES may require flanking sequences to adopt the conformation needed for CRM1 binding.
The increase of MEL-A probably enhances the density of an ordered conformation needed for the interaction with HIgG; this finally might impede the binding of HSA.
The authors are left with the speculation that the polymer may lock the subunits into a certain conformation, and block its switch to another conformation needed for activity.
Calcium would thus also have the effect of selecting the specific conformation needed for correctly anchoring the TnI to the system.
Alternatively, PfVAP1 and PfEMP1 may form a heterodimer at the surface of IE that stabilizes a PfEMP1 conformation needed for functional display to host receptors.
Instead of using Monte Carlo simulation to simulate thousands of possible paths through various conformational states, we were able to use Markov methods to calculate the steady state occupancy of each conformation, needing to calculate the energy of each conformation only once.
It is clear, however, that in reality — as well as with the synthetic data generated here — the distance restraints reflect a distribution of conformations, and that no single conformation needs to agree fully with the restraints.
The different conformations needed to build a geminivirus arise through differences in the N-terminal domain of the CP, rather than in its core fold.
Although methods with limited structural flexibility have proven successful at recapitulating consensus binding sequences from wild-type complex structures, conformational flexibility is likely important for design and template-based modeling, where non-native conformations need to be sampled and accurately scored.
Conformational sampling begins by identifying fragments from the rotamer library that are contained in the molecule of interest whose conformations need to be sampled.
