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From these results, we suggest that the amyloid oligomer conformation is present in a group of natively folded proteins.
A similar conformation is present in our B. anthracis DHPS structure which precludes a prediction of its role at the active site, although a conserved aspartic acid that has been implicated in catalysis [19] is present (Asp186).
Whilst the asymmetric conformation is present in two of the three strains sequenced, the BM407 conformation is likely to be the more common form of the S. suis chromosome as it maintains the replichore symmetry, placing the origin and terminus of replication at opposite ends of the circular chromosome, a common feature of bacterial circular chromosomes [102].
A second high-energy conformation is present in the ligand-bound simulation around 5% of the time.
As we did not observe short distances corresponding to the closed conformation, we conclude that only the open conformation is present in Snf7 polymers assembled on membranes.
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Docked ligand conformation, is presented with sticks and the binding pocket is shown as surface.
A strategy for the design and synthesis of simplified paclitaxel analogs based on the T-Taxol conformation is presented.
Of the resulting random docked protein-ligand conformations obtained (n = 7,000), the top binding energy conformation is presented in Figure 8B.
The binding conformation is presented in Figure 2. At this stage it can be hypothesized that ibuprofen prevents interaction between Ebola virus and ECM by blocking the interaction between GP1 and EMILIN.
The results indicated that the antiparallel β-pleated sheet (silk-II) conformation was present in the silk fibroin scaffolds.
It is owing to the fact that xanthan macromolecules, which adopt helical conformation, are present [ 25].
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