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The model suggests that the subthalamic nucleus computes conflict between evidence representing alternative choices, and its influence on the output nuclei delays choice on more conflicting trials until the conflict resolves.
Exclusion criteria were testosterone inhibiting medical treatment, insulin therapy, severe diabetic retinopathy, amputation of a lower limb, severe peripheral polyneuropathy, dementia, inability to speak Danish, and participation in other conflicting trials.
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This ambiguity exists not because of conflicting trial results, but because trials have not been conducted in this population.
Because of conflicting trial data, two meta-analyses were undertaken to synthesize the literature, including these RCTs as well as several others.
A variety of behavioral and structural interventions that reduce HIV-related risk behaviors are of possible, but uncertain utility, due to conflicting trial and study evidence [ 175, 254– 267].
7 This approach, however, merits caution and a deeper examination of available evidence, particularly as conflicting trial results have been reported from other settings such as Cameroon and Brazil.
These conflicting trial results have led to clinical equipoise regarding the benefits of prophylactic radiotherapy and calls from the mesothelioma community for a suitably powered RCT to conclusively establish its role.
The data regarding mastectomy in inflammatory breast cancer are conflicting: several trials have shown a benefit [ 26, 27] but others suggest that mastectomy offers no survival advantage [ 28, 29].
Conflict trials resulted more complex and time-consuming than no conflicts, requiring more frequent fixations and saccades.
We did not observe a specific speedup on high-conflict trials, which was a hallmark of the STN studies.
Compared to control subjects, MA abusers exhibited reduced RT adjustments and reduced activation in the prefrontal cortex (PFC) after conflict trials.
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