With the woman's agreement, a letter will be sent to her general practitioner confirming trial entry.
We contacted the investigators in several of the studies to confirm trial methodology and to clarify specific outcome data.
We then made a detailed evaluation of each record to confirm trial inclusion (BS and HM, checked by AB).
Moreover, the two CONFIRM trials were not addressed to the same patient population.
A prespecified integrated analysis of the randomized, double-blind, placebo-controlled, Phase 3 DEFINE and CONFIRM trials was conducted.
Also last week, the government released transcripts confirming that trial testimony of several witnesses appeared to conflict with what they had told the grand jury.
Those observations were confirmed by trials that evaluated an antibiotic discontinuation policy for patients with other infections [ 111, 131- 138].
The CONFIRM trial design has been described in detail previously [ 5].
Analysis of the expected DoR and expected DoCB showed fulvestrant 500 mg significantly increased expected DoCB compared with fulvestrant 250 mg in the CONFIRM trial.
Although earlier clinical trials of glatiramer had conflicting results, two more recent trials have demonstrated its efficacy in treating MS, that is, the phase-3, randomized CONFIRM trial [ 23- 26] and a large National Institutes of Health (NIH -sponsored (CombiRx Trial) [ 27].
