Among kinase inhibitors that affected DMT1-mediated iron uptake, staurosporine also reduced DMT1 phosphorylation confirming a role for serine phosphorylation in iron transport regulation.
The protective activity of RCC2 on apoptosis was revoked by a constitutively activated Rac1, confirming a role of RCC2 in apoptosis by regulating Rac1.
Indeed, we observed a statistically significant increased MAC deposition on all three ΔkatA strains further confirming a role of KatA in complement resistance.
Previous studies have shown that intact DA signalling in the NAc is necessary for acquisition of flavour conditioning37,38, confirming a role for NAc DA in mediating the reinforcing effects of nutritive solutions.
Finally, desmosomal and tight junction defects were also observed after microtubule disruption in nocodazole-treated tissue-engineered skins, thus confirming a role for microtubules in the maintenance of these types of cell junctions.
Those patients who engaged the right IFG more during Target-after-Neutral stimuli responded faster to targets, confirming a role of this region in coping with emotional distraction.
Thus all the spermatogenesis parameters examined indicate that spermatogenesis is compromised in CF mice, confirming a role of CFTR in spermatogenesis.
The prediction that males directly influence the longevity of their mates has been verified [13], confirming a role for inter-locus sexual conflict in the evolution of ageing.
Treatment of erythrocytic parasites with cysteine protease inhibitors or disruption of the falcipain-2 gene results in accumulation of undegraded hemoglobin in the food vacuole, confirming a role for this enzyme in hemoglobin hydrolysis [6], [10].
The hearts of mice deficient in the naturally occurring dominant negative isoform of Stat3, Stat3β, were completely resistant to HS-induced apoptosis confirming a role for Stat3, particularly Stat3α, in this process.
In addition, our results show that sphingolipid uptake is increased in uninfected GFP-Rab14wt overexpressing cells whereas sphingolipid accumulation inside cells overexpressing the GFP-Rab14 negative mutants is impaired, confirming a role for Rab14 in sphingolipid transport.
