Fourteen or more responses in 26 evaluable patients were required to confirm a response rate of 60% or higher (Fleming-A'Hern design), warranting further evaluation.
This post hoc analysis was also conducted to confirm a response threshold using an anchor-based and supportive distribution-based approach.
Having confirmed a response to glucocorticoids, we asked whether glucocorticoid treatment in vitro can mimic the improvement in myofibrillar structure evoked by GR activation in vivo in cardiomyocytes.
Tumour response was assessed according to RECIST criteria version 1.0 using magnetic resonance imaging (MRI) or computed tomography (CT) on day 21 (±4 days) of every even-numbered cycle, at the end of the study treatment, if disease progression was suspected or to confirm a response.
Bone marrow aspiration and/or biopsy was conducted before every other cycle for the first 3 months and then every 3 months, at the time of discontinuation and every 3 months during follow-up, and/or as clinically indicated or to confirm a response.
Computed tomography scans conducted a further 3 months later showed that the antitumour effect of imatinib had continued, confirming a partial response (PR).
There was no change in Txnip expression with exposure to 5 mM taurine, confirming a specific response to creatine rather than osmotic stress.
The leukocyte concentration in afferent lymph and the proportion of neutrophils in milk and afferent lymph, however, increased significantly to magnitudes that are in accordance with previous reports, clearly confirming an inflammatory response.
After confirming a sufficient contractile response to KPSS, experiments with noradrenaline (10−5 mol/L) were started to obtain phasic and tonic contractile responses [ 24].
Furthermore, BMP4 treatment induced non-CG-secreting day 31 chorionic girdle trophoblast cells to secrete CG, confirming a specific functional response to BMP4 stimulation.
