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This study successfully confirmed the implications of previous reports (27, 32) showing OCA to be a potent ligand for FXR.
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Among the 22 kinases identified as potential hits interfering with the up-regulation of CYP1A1 activity by our RNAi screen, we confirmed the implication of PNCK and ITPKA through screen-independent transfection of efficient siRNA.
Some of the CNVs are found to be implicated in complex diseases including neuropsychiatric, autoimmune diseases and so on [22] [25], but the association of CNVs with T2D remains largely unexploited except that a very recent study confirmed the implication of a previously identified human gene TSPAN8 [26].
Results obtained with MEF.Casp9−/− and MEF.Casp3/7 DKO cells confirmed the implication of the mitochondrial apoptotic route.
We also confirmed the implication of IL-8 (-251) T/A polymorphism in a larger cohort.
We confirmed the implication of PTEN in genesis of plexiform neurofibromas and MPNSTs in NF1.
We have confirmed the implication of CAV1 in MTX resistance in our HT29 cell line.
The resolution of the rodent PP1c-I2 crystructureconfirmedfirmed the implication of these regions in the binding process [ 37].
Evans et al. also confirmed the implication of carotid plaques as predictors of future CV events in RA.
The simultaneous staining of SSc PBL with DCFH-DA and anti-CD3 PerCP-conjugated antibody confirmed the implication of T cell population in ROS production.
Although these authors did not validate their findings in mammalian systems, we and others confirmed the implication of the proteasome in the response of human cells to CDDP.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com