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This finding confirmed that the decrease in protein stability is the main molecular pathogenic mechanism in PKU and the determinant for phenotypic outcome.
The result obtained from these studies ruled out the possibility of quenching of fluorescence of dye in presence of AuNPs and confirmed that the decrease in intensity on the absorption and emission spectra is mainly attributed to the reduction of dye catalyzed by AuNPs.
We confirmed that the decrease occurs in NK cells using cells purified from a second group of patients also receiving cART.
The microarray analysis confirmed that the decrease in HP1γ protein does not affect the expression level of 13 other genes reported to be associated with pluripotency [34] (Figure 2C).
First, we confirmed that the decrease in tubulin expression was time- and dose-dependent).
Control experiments confirmed that the decrease in CtpS polymerization was not due to mechanical disruption by substrate addition.
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Analysis of HSF1 transcriptional activity of aged worms confirmed that the decreased protein stability in aged body wall muscle cells was associated with a deteriorated induction of the heat shock response (Figure 4E and Figure 3A).
Indeed, using a self-quenched DQ-ovalbumin particle system, we confirmed that the decreased acidification of lysosomes of CHM patients significantly affected proteolytic abilities of the monocytes [25], [26].
This study confirmed that the decreased surgery rate in CM users reduced health care spending in uterine fibroid.
Thus, we confirmed that the decreases in PCSK1 and PCSK2 mRNA levels in AD hippocampus are indeed reflected in the levels of their translation products.
Our result confirmed that the decreased Necdin levels seen in aged mouse skeletal muscle can be reproduced with normal human fibroblasts in culture.
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