Sentence examples for confirmed segregation from inspiring English sources
Principal Component Analysis (PCA) confirmed segregation of irradiated and non-irradiated samples, whereas no segregation between the two groups of irradiated samples was detected, consistent with the HC (Fig. 2B).
Sanger sequencing confirmed segregation consistent with autosomal recessive inheritance (Fig. 1C).
Candidate variants were subsequently validated by Sanger sequencing, and, if confirmed, segregation was studied in additional affected family members when available (Table 2 ).
A recent study by Irish researchers further confirmed segregation of rumen microbial profiles in forage-fed beef heifers with different RFI values (Carberry et al., 2012).
Sequence analysis of additional family members confirmed segregation of the mutation with the phenotype and that the mutation was absent in 100 unrelated ethnically matched healthy controls, providing strong evidence that COL4A2 G702D represents the causative mutation.
Exome-sequenced variations were validated by additional Sanger sequencing to confirm segregation of filtered disease-causing single nucleotide variations.
Interestingly, segregation analysis of the mutations found in LCA-46 could only confirm segregation of p.Leu341Ser in the mother, suggesting that p.Ser121LeufsX6 occurred de novo (paternity confirmed).
Therefore, the missense variant in CHRNA1 is the most likely candidate mutation, although we could not confirm segregation due to lack of available tissue from previously affected fetuses.
Simultaneous analysis of multiple family members confirms segregation, enhancing the power to filter the genetic variation found and leading to rapid identification of the pathogenic variant.
Thereby, the identified terminating atomic planes/columns in boxes (1), (2), and (3) confirm segregation of Pt over the ordered particle core.
For the m.4175G>A mutation, significantly higher levels of mutation were detected in COX-positive RRF (89.0±24.2%n=211) than in COX-positive non-RRF (39.6±44.2%, n=11) (P=0.0025, two-tailed Student's t test), confirming segregation of the m.4175A genotype with a histopathological abnormality.
