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The 2,2-diphenyl-1-picrylhydrazyl assay confirmed potent free radical scavenging activity.
Approved by FDA because of its confirmed potent antineoplastic activity [ 52], etoposide is a widely used agent to treat various cancers including lung cancer, leukemias, non-Hodgking's lymphoma, testicular cancer, Kaposi's sarcoma, soft tissue sarcomas, and neuroblastoma.
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Our experimental approach confirms potent efficacy of LIF-NP for myelin repair in mice in vivo.
Binding free energies and dissociation constants (KD) determined by ITC for each bromodomain of human and murine BRDT confirm potent, specific (ratio 1 1) interactions with all domains (KD = 44 190 nM; Figure 1F).
The Stern Volmer plots in the designed photochemical reaction systems also confirmed a potent quenching effect of DFO on FR-mediated CL.
NKX2.5-eGFP and Troponin T expressing cells were also up-regulated in the Mesp1-mCherry population and enhanced by inhibition of the Wnt pathway which confirmed the potent cardiovascular specific differentiation.
Preclinical studies comparing the in vivo contraceptive efficacy of GM-4 and GM-144 versus nonoxynol-9-based detergent spermicide (Gynol II) in the rigorous rabbit model confirmed the potent contraceptive activity of these GMs.
Thus both in vitro and ex vivo studies involving small peptide as well as natural protein substrates confirmed the potent anti-furin activity of Eda-peptide (II).
In this assay, both compounds 1 and 2 were confirmed as potent hDAAO inhibitors.
These datasets confirmed the potent interest in tenascin-X as marker of serous ovarian cancer.
The induction of massive apoptosis and detectable maturation confirmed the potent anti-leukemic activity of the HDACi tested on AML1/ETO-expressing cells.
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