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Finally, because of this high conductivity values, the sample with higher glycerol content was tested in small electrochromic devices (ECD) that confirmed its potential for this kind of applications.
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113 Due to the substantial anatomical differences between the nasal cavity of rodents and humans, 114, 115 this approach likely needs to be evaluated in primates to confirm its potential for high levels of efficacy in human populations.
A specific metabolism prediction example of AZD9291 [32] further indicated its robustness in SOMs identification and metabolites generation, and also confirmed its potential applications for metabolism prediction.
In this study, gene expression analysis revealed that MCAM/CD146 was expressed at higher levels (>3-fold) in UC MSCs compared to fibroblasts, confirming its potential specificity for MSCs.
Furthermore, reverse genetics data show that all three subunits of the kinase are essential for the viability of the blood-stage parasite, confirming its potential as target for chemotherapeutic intervention.
This work culminated in the identification of the clinical candidate 15, which demonstrates preclinically the desired efficacy and safety profiles confirming its potential as an inhaled agent for the treatment of asthma.
Included among these are the pyrazolones, represented by hit structure 1 and lead compound 2. The lead pyrazolone 2 is neuroprotective in a cellular model of ALS using PC12-SOD1G93A cells and increases median survival time in an ALS transgenic mouse model by 13%, confirming its potential as a therapeutic candidate for ALS.
The increase in the research interest on alginate microparticles in pharmaceutical and biomedical areas confirms its potential use as an effective matrix for drug and cell delivery.
The excellent electrochemical properties demonstrated by the Si Ge Mo composite film electrode confirm its potential as an alternative anode material for lithium-ion batteries.
Large-scale studies are needed to confirm its potential as a diet diversification strategy for vegetarian population.
Given the data presented here, it would be of interest to explore the expression of SRC3 and its influence on outcome in cases entered into ICON3 and GOG-132 to confirm its potential usefulness as a potential biomarker for treatment selection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com