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The triterpenoids dihydrocelastrol and celastrol were identified as potent inducers of UPR signaling and cell death in a primary screen and confirmed in a panel of OSCC cells and other cancer cell lines.
This observation was confirmed in a panel of 9 additional cell lines with varying metastatic potential (data not shown).
This PVT1 and MYC protein coamplification was confirmed in a panel of 8 human primary tumors.
The association between cancer progression and reduced LARP7 expression was also confirmed in a panel of breast cancer cell lines.
Tivantinib antitumor activity was demonstrated in murine xenograft models and its efficacy was confirmed in a panel of HCC cell lines [ 83].
Concordant hypermethylation and corresponding gene silencing of sonic hedgehog pathway members ZIC1 and ZIC4 in OC tumors was confirmed in a panel of OC cell lines, and ZIC1 and ZIC4 repression correlated with increased proliferation, migration and invasion.
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The HOXB9 effect on global expressions of the EMT-related markers was further confirmed in a selective panel of key genes in a quantitative PCR assay.
His restricted expression to the placenta was further confirmed in a second cDNA panel prepared from normal tissues.
As shown in Fig. 3, differential DNA methylation between tumor and non-tumor breast samples was confirmed in an independent tissue panel.
And make no mistake: 2005 was a great year, as the wine panel confirmed in a recent tasting of 25 bottles of 2005 Chinon.
And in fact, plenty of fine barbera is produced, as the wine panel confirmed in a tasting of 25 bottles from the Alba and Asti sections of the Piedmont.
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