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This association was confirmed in a large group of CH patients and controls from Germany [85].
These results need to be confirmed in a large epidemiological study including clinical and physiological variables [33].
Amyloidosis is thought to be 1 of the risk factors, but this has not been confirmed in a large study.
In the following year, the lack of PERV infection was also confirmed in a large study of 160 patients published in Science (Paradis et al. 1999).
EVAR was considered to have short- and long-time survival advantages over open surgery, but this was not confirmed in a large randomised trial [32].
But the association of the alleles with ESAT-6 peptide presentation needs to be confirmed in a large cohort of subjects.
These results were confirmed in a large cohort of diabetic patients treated with metformin despite various metformin contraindications, in which no MALA has been described by the authors [2].
The evidence of clinical benefit of ESBL-E digestive colonization surveillance to predict the presence or the absence of ESBL-E in respiratory samples needs to be confirmed in a large prospective clinical study.
Our objective was to test, if this hypothesis derived from randomized controlled studies (RCTs) in outpatients, would be confirmed in a large naturalistic study in a cohort of inpatients with major depression.
Although preliminary data from a single trial of colchicine given for 1 month postoperatively (COPPS trial) were promising, the results have not been confirmed in a large, multicenter trial.
Most recently, a common polymorphism (rs2230199) in the complement component 3 (C3 [MIM 120700]) gene of complement cascade was associated with AMD in two case-control sets [35] and confirmed in a large case-control sample [36].
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