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Similar to these functional observations, we confirmed exacerbated reduced LV function in response to TAC along with cardiac hypertrophy and fibrosis as well as accentuated LV dilation after AngII infusion in Klf15 KO mice.
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These molecules include several inhibitors of the Fanconi anemia (FA) DNA repair pathway (which coordinates HR and TLS for the repair of interstrand crosslinks) and indeed were confirmed to exacerbate the cytostatic/cytotoxic potential of CDDP in FA-proficient but not in FA-deficient ovarian cancer cells.
Depletion from Foxp3hCD2 reporter mice in vivo confirmed that Foxp3+ cells exacerbated fungal burden and inflammatory renal disease.
Our study also confirmed that Sema4A can exacerbate the pathological progression by regulating the production of these cytokines in a synergistic way with LPS.
Additional studies should be conducted to confirm that HMPV exacerbates chronic obstructive pulmonary disease.
In the present study we confirm that OSM exacerbates the effects of both IL-1 and TNF-α with respect to bone breakdown, osteoclast formation and the expression of RANK/RANKL, and further confirm that this rapid model of inflammatory arthritis is suitable for studies of RA.
Hull City's injury problems have been exacerbated after it was confirmed that James Chester needs an operation.
A 2012 report confirmed that inequality in New Orleans has been exacerbated since Hurricane Katrina exposed the city's racial and socioeconomic divide.
A recent report confirmed that IBV and E. coli infection exacerbated ORT pathogenesis in adult laying hens [ 23].
Moreover, the ligation-induced experimental periodontitis exacerbated alveolar bone loss, which confirms the previous studies that postmenopause is a potential risk factor in the progression of periodontitis [ 4– 6].
Recent findings further confirm that monotherapy may exacerbate tumor relapse, as doxorubicin treatment actually promoted metastasis of murine 4T1 and human MDA-MB-231 cells, concurrent with activation of TGFβ signaling [ 75].
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